PK/PD modelling of glucose-insulin-glucagon dynamics in healthy dogs after a subcutaneous bolus administration of native glucagon or a novel glucagon analogue
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Relationship between Insulin to Glucagon Ratio and Metabolic Parameters in Primiparous and Multiparous Dairy Cows in Transitional Period
In order to investigate the relationship between insulin to glucagon ratio and metabolic factors in transitional period of dairy cows, 28 cows heifers with body condition score of 3.25- 3.75 were selected. Dairy cows received close up diet, from 21 days prepartum until parturition and lactation diet according to nutritional requirements after parturition. Blood was sampled at 10 days before and...
متن کاملPharmacodynamics and stability of subcutaneously infused glucagon in a type 1 diabetic Swine model in vivo.
BACKGROUND The objective of this study was to determine the in vivo pharmacodynamics of glucagon and to test its glycemic effect over days by assessing its time course of activity and potency in a type 1 diabetic swine model. METHODS Individual experiments were conducted in different pigs using glucagon preparations that were reconstituted on different days and stored at room temperature or n...
متن کاملDiscovery of Novel Glucagon Receptor Antagonists Using Combined Pharmacophore Modeling and Docking
Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...
متن کاملDiscovery of Novel Glucagon Receptor Antagonists Using Combined Pharmacophore Modeling and Docking
Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...
متن کاملDesigning a glycemic control strategy to maintain glucose homeostasis and prevent hypoglycemia for subjects with type 1 diabetes
This paper presents using the fractional PImDn controller module which manipulates insulin infusion rate to maintain normoglycemia in subjects with type 1 diabetes. To prevent severe hypoglycemia, a conventional proportional controller is used to regulate glucagon infusion rate when the blood glucose levels fall below a threshold. Two sets of controller parameters are obtained and evaluated. Fo...
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تاریخ انتشار 2017